Azithromycin Sulfate for Injection

This product is white or white loose block or powder.

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Classification:

Anti-infection class

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+86-579-82131973

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Verrodite

Azithromycin Sulfate for Injection Instructions

Please read the instructions carefully and use under the guidance of a physician.

[Name of Drug]]

Common Name: Azithromycin Sulfate for Injection

Product Name: Verouds

English Name:Azithromycin Sulfate for Injection

Chinese Pinyin:Zhusheyongliusuan aqimesu

[Ingredients] The main ingredient of this product is azithromycin sulfate, and its chemical name is: 9-deoxy -9α-aza-9αmethyl-9α-erythromycin A sulfate.

Chemical structural formula:

Molecular formula: C₃₈H₇₂N₂0₁₂ H₂S0₄

Molecular weight: 847．00

[character] this product is white or white loose block or powder.

Indications 1For Streptococcus pyogenes caused by acute pharyngitis, acute tonsillitis.

2For pneumonia caused by Streptococcus pneumoniae, influenza bacillus and Mycoplasma pneumoniae.

3For chlamydia caused by urethritis and cervicitis.

4For sensitive bacteria caused by acute bronchitis, acute exacerbation of chronic bronchitis.

5For skin and soft tissue infections caused by sensitive bacteria.

[Specification] 0.25g(25Ten thousand units), 0.5g(50Ten thousand units) (Press C₃₈H₇₂N₂0₁₂calculation)

Usage and dosage]This product is fully dissolved with appropriate amount of water for injection, prepared into each 1mlContaining 0.1gsolution, then add to 250mlor 500mlIn 0.9% sodium chloride injection or 5% glucose injection, the final azithromycin concentration is 1.0-2.0 mg/ml intravenous drip, drip time: 1 mg/ml, drip for 3 hours; 2 mg/ml, drip for 1 hour. For the treatment of community-acquired pneumonia, the adult dosage is 0.5g each time, once a day, for at least 2 consecutive days. Then switch to azithromycin oral preparation 0.5g/day, treatment for 7-10 days as a course of treatment. The timing of conversion to oral therapy should be determined by the physician based on clinical response. For the treatment of pelvic inflammatory disease, the adult dosage is 0.5g each time, once a day. After 1 day or 2 days of medication, azithromycin oral preparation O.25g is used instead, with 7 days as a course of treatment. The timing of conversion to oral therapy should be determined by the physician based on clinical response. If an anaerobic infection is suspected, an anti-anaerobic drug should be used.

adverse reaction]Occasion can appear dizziness, headache and fever, rash, joint pain and other allergic reactions, very rare anaphylactic shock and angioedema. A few patients may have transient neutropenia and elevated serum aminotransferase.

taboo]Erythromycin or other macrolide allergy is contraindicated.

[Note]]Patients with hepatic impairment should use this product with caution.

Medication for pregnant and lactating women]Animal experiments have shown that azithromycin has no effect on the fetus, but it is still inexperienced in the application of human pregnant women, so the application of azithromycin in pregnant women must fully weigh the advantages and disadvantages.

There is no information on whether azithromycin can be secreted into breast milk, and the use of azithromycin in lactating women should be considered with caution.

children's medication]6The dose and method of administration for children under 1 month of age have not been established. Treatment is less than 6.Otitis media, community-acquired pneumonia, and infants less than 2 monthsThe efficacy and safety of pharyngitis or tonsillitis in children aged 18 years has not been established.

elderly medication]This experiment was not performed and there are no reliable references.

drug interaction]lWhen combined with aminophylline, attention should be paid to monitoring the blood concentration of the latter.

2When combined with warfarin, the prothrombin time should be checked.

3and carbamazepine, digoxin combination, can make the carbamazepine, digoxin blood drug concentration level increased.

drug overdose]This experiment was not performed and there are no reliable references.

pharmacology and toxicology]Azithromycin is 15Metacyclic macrolides, the first variety of nitrogen lactones. Its mechanism of action is the same as that of erythromycin, mainly with the 50s of bacterial ribosomes.The subunits bind to and inhibit RNA-dependent protein synthesis. This product has good antibacterial effect on Streptococcus pyogenes, Streptococcus pneumoniae and influenza bacillus, and also has antibacterial activity on Staphylococcus. This product on Staphylococcus, Streptococcus and other Gram-positive cocci antibacterial effect is slightly worse than erythromycin on influenza bacilli and Moraxella catarrh antibacterial effect than erythromycin 4~8 times and 2~4 times, on a small number of Escherichia coli, Salmonella, Shigella can also have antibacterial effect. This product has good antimicrobial effect on anaerobic bacteria such as digestive streptococcus, mycoplasma pneumoniae and chlamydia trachomatis.

[Pharmacokinetics] This product is widely distributed in the body, and its concentration in various tissues can reach l0 of that in the same period.～100Times. This product has high concentration in macrophages and fibroblasts, the former can transport azithromycin to the site of inflammation. Half-life after single-dose administration of azithromycin (t_l_／2) for 35~48 hours, more than 50% of the dosage is excreted through biliary tract in the original form, and about 4.5 is excreted with urine in the original form within 72 hours after administration.

[Storage] Closed and stored in a cool place (No more than 20C).

[packaging] glass bottle, 0．25g× 2 bottles/box, 0.25g × 1 bottle/box, 0.5g × 1 bottle/box.

Period of Validity 24Months.

[Implementation Standard] WS-359(X-305)-2002(1)(0．25g); WS-359(X-305) one 2002(2)(0.5g)

[approval number] national medicine standard word H20000728(0．25g )Chinese medicine standard word H20000729(0.5g).

production enterprise]

Company: Zhejiang Jianfeng Pharmaceutical Co., Ltd.

address: zhejiang jinhua city industrial park binhong road l756No.

Postal Code: 321016

Code anti-counterfeiting query method]

Scratch off the anti-counterfeiting mark coating, that is, a group of l6For the number of digits, dial 8008202086Toll-free telephone (after connecting, press the voice to enter l6 inquiry number in turn, press#key, press * when the input is wrong *Key re-enter), telephone voice can automatically tell whether the drug is genuine. In areas where 800 telephone is not available, short message or online inquiry can be used: mobile (1111112), Unicom (9111112), website (www.yesno.com.cn).

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