Ofloxacin Ear Drops
For the treatment of sensitive bacteria caused by otitis media, otitis externa, tympanitis.
Key words:
Ofloxacin Ear Drops
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Instructions for Ofloxacin Ear Drops
Please read the instructions carefully and use them under the guidance of a physician.
[Name of Drug]]
Common Name: Ofloxacin Ear Drops
English name: 0 floacin Ear Drops
Hanyu Pinyin: Yangfushaxing Di’erye
[Ingredients] The main ingredients and chemical name of this product: The main ingredient of this product is ofloxacin. Its chemical name (±)A 9 fluorine a 2, 3One dihydrogen, one 3 methyl, one l0 (4 methyl, one l, one piperazinyl), one 7 oxo, one 7H, one pyridino [1,2,3 de], one [1,4] benzoxazine, one 6 carboxylic acid.
Chemical structural formula:

Molecular formula:C18H20FN304
Molecular weight:361.38
[character] this product is light yellow green clear liquid.
[indications] for the treatment of sensitive bacteria caused by otitis media, otitis externa, tympanitis.
[Specifications] 5ml:15mg (Based on ofloxacin)
[Usage and dosage] ear drops. Adults 6-10 at a timeDrops, one day 2~ 3 times. Ear bath for about 10 minutes after ear drops. Increase or decrease the number of ear drops according to the symptoms, and decrease the number of drops for children.
[adverse reactions] occasional middle ear pain and itching.
[contraindication] for this product and fluoroquinolones allergic patients disabled.
[Precautions] lIt is only used for ear point.
2This product is generally applicable to otitis media limited to the middle ear mucosa part of the local treatment if inflammation has diffuse and around the tympanic cavity, in addition to local treatment, should also take oral pharmaceutical.
3If the temperature of the medicine is too low when using this product, it may cause dizziness. Therefore, the use temperature should be close to body temperature.
4Allergic symptoms should be stopped immediately.
5The course of treatment with this product is 4Week is limited, if continue to be administered, should be used with caution.
[Medication for pregnant women and lactating women] Pregnant women should not be used. If there are indications for application, and the advantages outweigh the disadvantages, it can be used with caution. Lactation should be stopped when used by lactating women.
[Children's medication] This product is generally not used for infants and young children.
[Drug Interactions] Long-term use of large amounts of local absorption, can produce the same drug interactions as systemic medication, such as cyclosporine, probenecid and other drugs increased blood concentration, interfere with the metabolism of caffeine.
[Pharmacology and Toxicology] This product has a broad-spectrum antibacterial effect, especially for aerobic gram-negative bacilli. It has a good antibacterial effect on the following bacteria in vitro: most of the bacteria in the family Enterobacteriaceae. Including citric acid bacillus, cloacae, Enterobacter aerogenes and other Enterobacter, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It also has antibacterial activity against multidrug-resistant bacteria. Penicillin-resistant Neisseria gonorrhoeae, enzyme-producing influenza bacilli and Moraxella have high antibacterial activity. It has an antibacterial effect against most strains of the genus Pseudomonas, such as Pseudomonas aeruginosa.
This product has antibacterial activity against methicillin-sensitive staphylococcus, and has only moderate antibacterial activity against Streptococcus pneumoniae, hemolytic streptococcus and Enterococcus faecalis. It has good antimicrobial activity against Chlamydia trachomatis, Mycoplasma, and Legionella. It also has antibacterial activity against Mycobacterium tuberculosis and atypical mycobacteria. Poor antibacterial activity against anaerobic bacteria.
Ofloxacin, a fungicide, acts on bacterial DNA helicase by Asubunits that inhibit DNA synthesis and replication leading to bacterial death.
[Pharmacokinetics] According to the literature, adult patients in the middle ear cavity 0 3% ofloxacin solution, once 10Drops, 2 times a day, a total of 14 times, the blood concentration after 30 minutes of ear bath is very low, 0.009~0.012 ug/ml. Pediatric patients in the middle ear cavity ear drops once, ear bath 0.3% ofloxacin aqueous solution 5 drops, l20 minutes after the serum concentration is low, not more than 0.013ug/ml.
[storage] shading, airtight preservation.
[packaging] plastic drop bottle, 5ml per bottle.
[Validity] 24 months
[Implementation Standard] "Chinese Pharmacopoeia" 2005 Edition II
[Approval No.] Chinese Medicine H10950049
production enterprise]
Company: Zhejiang Jianfeng Pharmaceutical Co., Ltd.
Address: 368, Jinqu Road, Jinhua Industrial Park, ZhejiangNo.
Postal Code: 321016
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