Vitamin C should never be used in conjunction with these 28 drugs.


Release time:

2023-02-14

Vitamin C is mainly used in clinical treatment of vitamin C deficiency disease and vitamin C supplement treatment. Customers often buy vitamin C supplement in order to improve immunity. Do you know which drugs cannot be combined with vitamin C?

Vitamin C is mainly used in clinical treatment of vitamin C deficiency disease and vitamin C supplement treatment. Customers often buy vitamin C supplement in order to improve immunity. Do you know which drugs cannot be combined with vitamin C?

1. Compound Akwood Aluminum Magnesium and Vitamin C
Compound Aucianthus aluminum and magnesium is a kind of gastric mucosal protective agent, which can interfere with the absorption and removal of vitamins and affect the therapeutic effect of vitamins. Therefore, compound Aucianthus aluminum and magnesium should be avoided in combination with vitamin C.


2. Sulfonamides and vitamin C
Sulfadiazine, sulfamethoxazole and other sulfonamides combined with vitamin C on the one hand will increase the excretion of vitamin C and reduce its therapeutic effect; on the other hand, if the two drugs are used for long-term treatment, large doses of vitamin C It will promote the crystallization of sulfonamides in the kidneys, so the combination of the two drugs should be avoided.


3. Sodium Bicarbonate and Vitamin C
Sodium bicarbonate is alkaline, vitamin C is acidic, the combination of the two drugs will occur neutralization reaction, so that the efficacy of the two drugs are reduced, so the two drugs should be avoided.


4. Erythromycin and vitamin C
Erythromycin belongs to macrolide antibacterial drugs, its antibacterial effect will increase with the increase of pH value in alkaline environment, while vitamin C is acidic. Erythromycin will be decomposed and destroyed in acidic environment, affecting its antibacterial effect, so erythromycin should not be combined with vitamin C.


5. Vitamin B and Vitamin C
Vitamin B is an amphoteric compound, which is more oxidative than reductive. However, vitamin C has strong reducibility. When vitamin C is combined with vitamin B, a redox reaction will occur. Vitamin C will cause vitamin B to be destroyed into reductive vitamin B and lose its curative effect. Therefore, vitamin B should not be used in combination with vitamin C.


6. Vitamin B12 and Vitamin C
Taking large doses of vitamin C will destroy the synthesis of vitamin B12 in the liver, so people with vitamin B12 deficiency should not take a large amount of vitamin C to avoid anemia.


7. Vitamin K and Vitamin C
Vitamin C has a strong reducibility, while vitamin K has a certain oxidation. After the two drugs are compatible, a redox reaction will occur. Vitamin K is easy to cause failure, so the two drugs should not be combined.


8. Calcium and vitamin C
Taking large doses of vitamin C will cause calcium to form crystals in the kidneys, so vitamin C should be avoided in combination with calcium.


9. Ciprofloxacin and Vitamin C
Vitamin C can reduce the oral bioavailability of ciprofloxacin and reduce the absorption of ciprofloxacin, thereby reducing its efficacy. Therefore, it is necessary to adjust the dosage of ciprofloxacin or switch to ofloxacin for treatment when the two drugs are combined.


10. deferoxamine and vitamin C
Vitamin C can promote the complexation of deferoxamine to iron, increase the excretion of urinary iron and reduce its efficacy, so the dosage of deferoxamine can be appropriately increased during the combination of the two drugs.


11, Propranolol and Vitamin C
After taking propranolol and vitamin C at the same time, vitamin C will significantly reduce the average peak plasma concentration and the area under the curve of propranolol, which will affect the therapeutic effect of propranolol. Therefore, it is suggested to stagger the taking time of propranolol and vitamin C or appropriately increase the dosage of propranolol according to the patient's condition.


12. Methacholine Vinegar and Vitamin C
Methacholine is a M cholinergic receptor agonist, which can increase bronchial secretion by constricting bronchial smooth muscle. However, after combined with vitamin C, because vitamin C affects the metabolism of arachidonic acid and interferes with the production of prostaglandins, it can reduce the airway response caused by methacholine. Therefore, it is necessary to appropriately increase the dose of methacholine during the combination of the two drugs, so as not to affect the therapeutic effect.


13. Ferrous Fumarate and Vitamin C
After ferrous fumarate and vitamin C are combined, vitamin C can promote the absorption of ferrous fumarate, but it will also increase the probability of gastrointestinal reactions. Therefore, it is necessary to pay close attention to the gastrointestinal reactions during the combination of the two drugs. Happening, if necessary, the dosage should be reduced in time.


14. Ethinylestradiol and Vitamin C
Oral administration of 1g vitamin C can increase the bioavailability of ethinylestradiol to 60% ~ 70%, so the dosage should be adjusted when the two drugs are combined.

 

15, Anticoagulants and Vitamin C

Oral administration of large doses of vitamin C can interfere with the anticoagulant effect of heparin, warfarin sodium and other drugs, and shorten the prothrombin time. Therefore, the dosage of vitamin C should be adjusted at any time according to the anticoagulant effect during the combination period.

 

16. Acetylcysteine and Vitamin C
Vitamin C is an acidic drug, which will reduce its efficacy when combined with acetylcysteine. Therefore, it is necessary to pay close attention to the therapeutic effect of acetylcysteine during the combination period, and adjust the dosage or replace other drugs for symptomatic treatment if necessary.


17. Folic acid and vitamin C
Vitamin C is an acidic drug. When taken at the same time as folic acid, vitamin C will inhibit the absorption of folic acid in the gastrointestinal tract and promote the rapid decomposition of folic acid in an acidic environment, resulting in a decrease in the efficacy of folic acid. Therefore, in clinical application for the treatment of anemia, it is recommended that the two drugs be taken at a staggered time, with an interval of 1 hour.


18, Dyclonine and Vitamin C
The crushing of vitamin C tablets on the wound will play a role in wound healing, dyclonine has a certain analgesic effect, but the combination of the two will affect the dissociation value of dyclonine because of the difference in pH value, resulting in a delay in its action time, so the combination of the two drugs is not recommended.


19. Tetracycline antibiotics and vitamin C
Tetracycline antibacterial drugs such as tetracycline, oxytetracycline, chlortetracycline and vitamin C can increase the excretion of vitamin C. Therefore, the dosage of vitamin C should be appropriately increased during the combination of the two drugs.


20. Aspirin and Vitamin C
Salicylic acid contained in aspirin will produce salicylate after being metabolized by liver drug enzymes. These salicylates are mainly excreted through kidney, and the excretion is easily affected by urine pH value. The excretion rate of salicylate in acidic urine is less than 5%, while vitamin C has the effect of acidifying urine. Therefore, aspirin combined with vitamin C will reduce the excretion of salicylate, thus easily causing salicylate poisoning. From this point of view, aspirin and vitamin C should not be combined.


21. Barbiturates and Vitamin C
Barbiturates such as phenobarbital, barbital and pentobarbital will increase the excretion of vitamin C when combined with vitamin C, so the dosage of vitamin C should be appropriately supplemented for long-term use.


22. Theophyalines and Vitamin C
Vitamin C can reduce the oral absorption rate of theophylline drugs and weaken its antiasthmatic effect. Therefore, if the absorption of theophylline drugs is poor when taking vitamin C and theophylline drugs at the same time, rapid absorption tablets or liquid preparations should be considered instead, so as not to affect the therapeutic effect.


23, Perphenazine and Vitamin C
Perphenazine is a psychotropic drug. When combined with vitamin C, it can reduce the content of vitamin C in the body. In addition, after the two drugs are taken orally at the same time, vitamin C will reduce the effectiveness of perphenazine and weaken the antipsychotic effect of perphenazine. Therefore, the two drugs should not be combined.


24. Phenytoin and Vitamin C
Phenytoin sodium aqueous solution is alkaline, and phenytoin precipitation can be precipitated in acidic environment, while vitamin C injection is acidic. If the two injection preparations are injected together, white precipitation will be precipitated, so the injection preparations of the two drugs should not be compatible. In addition, for the oral preparations of the two drugs, after the combination of vitamin C oral preparation and phenytoin sodium oral preparation in the body, vitamin C can easily hinder the absorption of phenytoin sodium in the body, thereby reducing the bioavailability of phenytoin sodium. Reduce its efficacy. Therefore, if it is necessary to use oral preparations in combination, the blood concentration of phenytoin sodium should be closely monitored and the dosage of phenytoin sodium should be adjusted in sodium in sodium in time.


25. Mitomycin and Vitamin C
When mitomycin and vitamin C are administered intravenously at the same time, vitamin C can reduce the therapeutic effect of mitomycin, so the two drugs should not be used in combination.


26. Metronidazole and vitamin C
After mixing metronidazole injection and vitamin C injection, the solution will change color, the color of the solution will become darker, and the content of metronidazole in the mixture will be significantly reduced. However, the high concentration of metronidazole injection diluted and then added vitamin C injection after 24 hours of color no significant change. However, for the sake of safety, it is recommended that the two drugs be administered separately.


27. Norfloxacin and Vitamin C
Norfloxacin injection has a certain oxidation, and vitamin C has a strong reducibility, the two drugs at the same time after intravenous drip oxidation-reduction reaction will occur, precipitation of insoluble particles, increase the incidence of adverse reactions.


28. Levodopa, Vitamin C
Vitamin C can interfere with the absorption of levodopa in the body and reduce the therapeutic effect of levodopa. Therefore, the therapeutic dose of levodopa should be appropriately increased when the two drugs are combined.

It can be seen that vitamin C can not be used if you want to use it. Inappropriate use will not enhance the therapeutic effect, but will bring adverse reactions or reduce the therapeutic effect. Therefore, vitamin C should be correctly understood and scientifically supplemented. Under normal circumstances, the dose of vitamin C supplement for adults and early pregnant women is 100mg per day, and the dose of vitamin C supplement for middle and late pregnant women and lactating women is 130mg per day. Vitamin C can also be appropriately supplemented when catching a cold, but it is not suitable for long-term use, generally 3-5 days is appropriate.



In addition to the need to pay attention to the combination of vitamin C oral preparations taboo, but also to pay attention to the injection preparation is not compatible with the drug, vitamin C because of its strong reducibility, and the nature of instability, see the light is easy to accelerate the decomposition, so the need to avoid light preservation and suggest a separate intravenous drip.
 

Vitamin C seems to be an ordinary drug, and there are many incompatibility taboos that need to be paid attention to. Special attention should be paid to the clinical application to achieve safe, effective and reasonable use.